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Forsigtighed ved søvnapnø (korte perioder med pauser i vejrtrækningen less than søvn). Dosis skal muligvis sænkes. Phenobarbital og andre epilepsimidler kan øge OxyContin® Depot sløvende og åndedrætshæmmende virkning. kramper. Desuden kan der opstå en stærk trang til atter at indtage stoffet. Ved ophør af behandlingen skal dosis der